Agouti-related protein-deficient mice display an age-related lean phenotype
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چکیده
منابع مشابه
Age-Related Retinopathy in NRF2-Deficient Mice
BACKGROUND Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays key roles in retinal antioxidant and detoxification responses. The purposes of this study were to determine whether NRF2-deficient mice would develop AMD-like retinal pathology with aging and t...
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Qiaoqiao Shi,1* Kenneth J. Colodner,2* Sarah B. Matousek,1† Katherine Merry,2† X Soyon Hong,2 Jessica E. Kenison,1 Jeffrey L. Frost,1 Kevin X. Le,1 Shaomin Li,1 X Jean-Cosme Dodart,3 Barbara J. Caldarone,3 Beth Stevens,2 and X Cynthia A. Lemere1 1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, 2Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s H...
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The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via microglia-mediated pruning of inappropriate synapses during brain development. However, less is known about the role of complement during normal aging. Here, we studied the role of the central complement component, C3, ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2005
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2005.11.004